Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. Our studies are focused on evolutionarily conserved…Read More
Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell…Read More
Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the…Read More
We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics at the Memorial Sloan Kettering Cancer Center. We carry out research in cancer biology and pediatric oncology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.