Functional proteomics
and genomic plasticity of pediatric cancers

Genomic plasticity and DNA transposases in childhood tumors

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. (more…)

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Epigenetic signaling and rational therapy of acute myeloid leukemia

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell…

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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the…

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Kentsis Research Group Overview

We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics at the Memorial Sloan Kettering Cancer Center. We carry out research in cancer biology and pediatric oncology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

Projects

Genomic plasticity and DNA transposases in childhood tumors
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Epigenetic signaling and rational therapy of acute myeloid leukemia
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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes
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Publications

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MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia
NatureGenetics2017
PGBD5 promotes site-specific oncogenic mutations in human tumors
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Forward genetic screen of human transposase genomic rearrangements

Blog

Rational combination therapy for acute myeloid leukemia
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Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in solid tumors
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ProteoModlR for quantitative proteomics pathway modeling
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