Functional proteomics
and genomic plasticity of pediatric cancers

Genomic plasticity and DNA transposases in childhood tumors

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. Our studies are focused on evolutionarily conserved…

Read More

Epigenetic signaling and rational therapy of acute myeloid leukemia

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell…

Read More

High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the…

Read More

Kentsis Research Group Overview

We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics at the Memorial Sloan Kettering Cancer Center. We carry out research in cancer biology and pediatric oncology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

Projects

Genomic plasticity and DNA transposases in childhood tumors
Read More
Epigenetic signaling and rational therapy of acute myeloid leukemia
Read More
High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes
Read More

Publications

Screen Shot 2016-08-28 at 6.50.56 AM
Forward genetic screen of human transposase genomic rearrangements
papers-img02
Genomic DNA transposition induced by human PGBD5.
papers-img01
Integrating genomics into clinical pediatric oncology using the molecular tumor board at MSKCC.

Blog

ProteoModlR for quantitative proteomics pathway modeling
Read More
Next-Gen Methods in Pharmacology
Read More
Human PGBD5 induces DNA transposition
Read More