Interact

Category archives for Interact

Dec 12, 2018

UltraQuant: Open framework for running MaxQuant mass spectrometry proteomics algorithms on Linux computer clusters

While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…

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Oct 04, 2018

Reliable commercial antibodies for PGBD5

A few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…

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Jul 25, 2018

Engineering scarless chromosomal rearrangements using homology-mediated recombination and selection

Genetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…

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Jan 09, 2018

Targeting oncogenic transcription factors

Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…

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Oct 26, 2017

Ultra-sensitive high-accuracy quantitative proteomics of complex biological systems and diseases

As we and others have described recently, modern mass spectrometry permits quantitative and sensitive measurements of both protein abundance and their chemical modifications, as proxies of biological and pathological activities.…

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