Is it possible to use cross-linking mass spectrometry to identify protein-protein interactions in living cells?
Cross-linking mass spectrometry is a powerful tool to elucidate protein-protein interactions and macromolecular structure based on cross-linker distances between specific amino acid residues. In a recent study led by Zheng…Read More
UltraQuant: Open framework for running MaxQuant mass spectrometry proteomics algorithms on Linux computer clusters
While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…Read More
Genetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…Read More