Jan 09, 2018

Targeting oncogenic transcription factors

Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…

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Oct 26, 2017

Ultra-sensitive high-accuracy quantitative proteomics of complex biological systems and diseases

As we and others have described recently, modern mass spectrometry permits quantitative and sensitive measurements of both protein abundance and their chemical modifications, as proxies of biological and pathological activities.…

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Jul 20, 2017

Rational combination therapy for acute myeloid leukemia

Functional genomics technology has brought numerous advances to cancer biology and to the discovery of new therapeutic targets. Now, collaborative research that was carried out with many colleagues across the country…

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  • Alex Kentsis

Mar 12, 2017

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in solid tumors

While some human cancers occur as a result of age-dependent accumulation of genetic mutations, and others are caused by deficiencies in DNA replication or repair, the causes of many oncogenic…

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Dec 31, 2015

ProteoModlR for quantitative proteomics pathway modeling

To enable quantitative analysis of post-translational protein modifications, Paolo Cifani and Mojdeh Shakiba in the lab developed ProteoModlR, a R program for quantitative analysis of relative and absolute abundance and…

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