Interact

Mar 12, 2017

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in solid tumors

While some human cancers occur as a result of age-dependent accumulation of genetic mutations, and others are caused by deficiencies in DNA replication or repair, the causes of many oncogenic…

Read More

Dec 31, 2015

ProteoModlR for quantitative proteomics pathway modeling

To enable quantitative analysis of post-translational protein modifications, Paolo Cifani and Mojdeh Shakiba in the lab developed ProteoModlR, a R program for quantitative analysis of relative and absolute abundance and…

Read More

Nov 02, 2015

Next-Gen Methods in Pharmacology

Welcome to the course page for Next-Gen Methods in Pharmacology! Graduate Program in Pharmacology, Weill Cornell Medical College and Sloan Kettering Institute Course Directors: Michael Kharas & Alex Kentsis This…

Read More

Sep 27, 2015

Human PGBD5 induces DNA transposition

Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…

Read More

Jul 24, 2015

Native proteome extraction using poloxamer-based adaptive focused sonication

Recent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…

Read More