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Jun 28, 2019

Ultrasensitive pathway-scale functional proteomics using the Quantitative Cell Proteomics Atlas at Single Cell Proteomics 2019

Jun 05, 2019

Is it possible to use cross-linking mass spectrometry to identify protein-protein interactions in living cells?

Cross-linking mass spectrometry is a powerful tool to elucidate protein-protein interactions and macromolecular structure based on cross-linker distances between specific amino acid residues. In a recent study led by Zheng…

Dec 12, 2018

UltraQuant: Open framework for running MaxQuant mass spectrometry proteomics algorithms on Linux computer clusters

While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…

Oct 04, 2018

Reliable commercial antibodies for PGBD5

A few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…

Jul 25, 2018

Engineering scarless chromosomal rearrangements using homology-mediated recombination and selection

Genetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…