Genetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
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Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
Read MoreAs we and others have described recently, modern mass spectrometry permits quantitative and sensitive measurements of both protein abundance and their chemical modifications, as proxies of biological and pathological activities.…
Read MoreFunctional genomics technology has brought numerous advances to cancer biology and to the discovery of new therapeutic targets. Now, collaborative research that was carried out with many colleagues across the country…
Read MoreWhile some human cancers occur as a result of age-dependent accumulation of genetic mutations, and others are caused by deficiencies in DNA replication or repair, the causes of many oncogenic…
Read MoreStructural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 https://t.co/mG7hD1zPHF #bioRxiv
There is still no convincing evidence for the frequent occurrence of posttranslationally spliced HLA-I peptides: https://t.co/DXIDj3qnmC
Psyched to share our work defining the structural basis of DCAF15-dependent RBM39 molecular glue degraders, now posted for feedback on BioRXIV. Congrats Dirk, Jonathan, Josh & colleagues. Gorgeous work, NIBR TPD rules
