Discovery of biomarkers for improved precision in oncology remains a critical problem. This is particularly pressing for cancers that currently lack adequate markers for stratification of chemotherapy and targets for…
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Cross-linking mass spectrometry is a powerful tool to elucidate protein-protein interactions and macromolecular structure based on cross-linker distances between specific amino acid residues. In a recent study led by Zheng…
Read MoreWhile computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…
Read MoreA few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
Read MoreLandmark work by #MSKKids for this terrible disease without effective therapies.
Really proud to play even a small part in this study - out today in JCO. "B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study" https://ascopubs.org/doi/pdf/10.1200/JCO.20.01974#.X5xBExGnYic.twitter
Here's our latest manuscript up on BioRxiv, supported by NCI's Cancer Moonshot #Ewing #Sarcoma:
The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma
https://www.biorxiv.org/content/10.1101/2020.10.29.355859v1
A laudable example! HHMI donation for use of HeLa cells https://www.nature.com/articles/d41586-020-03042-5
