Genetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
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Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
Read MoreAs we and others have described recently, modern mass spectrometry permits quantitative and sensitive measurements of both protein abundance and their chemical modifications, as proxies of biological and pathological activities.…
Read MoreFunctional genomics technology has brought numerous advances to cancer biology and to the discovery of new therapeutic targets. Now, collaborative research that was carried out with many colleagues across the country…
Read MoreWhile some human cancers occur as a result of age-dependent accumulation of genetic mutations, and others are caused by deficiencies in DNA replication or repair, the causes of many oncogenic…
Read MoreLandmark work by #MSKKids for this terrible disease without effective therapies.
Really proud to play even a small part in this study - out today in JCO. "B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study" https://ascopubs.org/doi/pdf/10.1200/JCO.20.01974#.X5xBExGnYic.twitter
Here's our latest manuscript up on BioRxiv, supported by NCI's Cancer Moonshot #Ewing #Sarcoma:
The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma
https://www.biorxiv.org/content/10.1101/2020.10.29.355859v1
A laudable example! HHMI donation for use of HeLa cells https://www.nature.com/articles/d41586-020-03042-5
