Recent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
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This protocol describes a modified version of flanking sequence exponential anchored (FLEA) PCR. The original FLEA-PCR method was developed to amplify integration sites of retroviruses or retro-transposons. Such transposons contain…
Read More[caption id="attachment_287" align="alignnone" width="720"] Conor O'Donnell (UC Dublin), Mondira Ray (Pitt), Camila Villasante (Johns Hopkins), Huong Tang (UMass).[/caption]
Read MoreWe are thrilled to welcome Lauren Forbes as a PhD thesis student. Lauren is a graduate student in Pharmacology, with an interest in drug design and cancer therapeutics. She obtained…
Read MoreMiniaturization of columns for liquid chromatography has greatly enhanced its sensitivity and resolution. Here, we provide a detailed protocol that describes the fabrication of fused silica capillaries with frits and their packing with…
Read MoreSmall world: who do I see while visiting @Stanford but my @sloan_kettering colleague @whitefishlab who is doing the same.
Wonderful to see this story of the first ever @US_FDA approved therapy for patients with BPDCN in press @NEJM. A true multicenter collaborative effort with special thanks to @doctorpemm, everyone at @Stemline, and of course, our patients. https://t.co/3WuunXa2Qc https://t.co/8rSFtrBTYc
#covalent #PROTACs work! Happy to share the results of this collaborative work on HaloPROTACs @HTovell @chiaramaniaci @mrcppu and @alessiociulli https://t.co/nyXYym982M
The electron beams (cryo EM and micro ED) are here to stay. Things are advancing rapidly - a report from a symposium yesterday:
https://t.co/JewrOOgAMf
Nice to see this finally published: Engineered peptide barcodes for in-depth analyses of binding protein libraries https://t.co/qeu9bvsaWE
