A few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
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Genetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
Read MoreDysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
Read MoreAs we and others have described recently, modern mass spectrometry permits quantitative and sensitive measurements of both protein abundance and their chemical modifications, as proxies of biological and pathological activities.…
Read MoreFunctional genomics technology has brought numerous advances to cancer biology and to the discovery of new therapeutic targets. Now, collaborative research that was carried out with many colleagues across the country…
Read MoreCongratulations to Lisa Mohr and Eléonore Toufektchan on our paper: ER-directed TREX1 limits cGAS activation at micronuclei published online today @MolecularCell @CellPressNews
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30958-8
I’m excited to present SubMARine (with @lsunderm, @jwintersinger, @gxr, @jensstoye) that, in polynomial time, reconstructs all cancer phylogenies (i.e., clone trees) consistent with mutation freq data from bulk tumor samples. https://doi.org/10.1371/journal.pcbi.1008400
Gorgeous work by @adrienne_boire and @BSantomasso, check it out! https://twitter.com/Cancer_Cell/status/1351256426228813824
Online Now: Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients http://dlvr.it/RqrJwX
