To enable quantitative analysis of post-translational protein modifications, Paolo Cifani and Mojdeh Shakiba in the lab developed ProteoModlR, a R program for quantitative analysis of relative and absolute abundance and…
Read More
Welcome to the course page for Next-Gen Methods in Pharmacology! Graduate Program in Pharmacology, Weill Cornell Medical College and Sloan Kettering Institute Course Directors: Michael Kharas & Alex Kentsis This…
Read MoreTransposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreThis protocol describes a modified version of flanking sequence exponential anchored (FLEA) PCR. The original FLEA-PCR method was developed to amplify integration sites of retroviruses or retro-transposons. Such transposons contain…
Read MoreStructural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 https://t.co/mG7hD1zPHF #bioRxiv
There is still no convincing evidence for the frequent occurrence of posttranslationally spliced HLA-I peptides: https://t.co/DXIDj3qnmC
Psyched to share our work defining the structural basis of DCAF15-dependent RBM39 molecular glue degraders, now posted for feedback on BioRXIV. Congrats Dirk, Jonathan, Josh & colleagues. Gorgeous work, NIBR TPD rules
