While some human cancers occur as a result of age-dependent accumulation of genetic mutations, and others are caused by deficiencies in DNA replication or repair, the causes of many oncogenic…
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To enable quantitative analysis of post-translational protein modifications, Paolo Cifani and Mojdeh Shakiba in the lab developed ProteoModlR, a R program for quantitative analysis of relative and absolute abundance and…
Read MoreWelcome to the course page for Next-Gen Methods in Pharmacology! Graduate Program in Pharmacology, Weill Cornell Medical College and Sloan Kettering Institute Course Directors: Michael Kharas & Alex Kentsis This…
Read MoreTransposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreHow do DNA-binding proteins engage specific sites “hidden” in chromatin? Recent cryoEM studies shed light on mechanisms @KurumizakaLab @CramerLab TaipaleLab, @SchubelerLab @LabThoma
https://authors.elsevier.com/a/1dGBbL7PXe%7Eh%7E
Proteomics folks, we are trying to look for mass spectral evidence of branched peptides, where fragment spectra may content a large lysine adduct and many will be chimeric from co-fragmentation of branches. 1/n
Happy birthday to Nobel laureate Dr. Barbara McClintock! 🎉🎂 Learn more about this pioneer who pushed on with her research in the face of every challenge, saying, “They said I was crazy—absolutely mad...When you know you are right you don’t care!” https://www.cshl.edu/barbara-mcclintock-free-to-discover/
Out today in Clinical Cancer Research (@CCR_AACR ), our preclinical study of combined JAK, CDK4/6, and PIM kinase inhibitors in MPN. https://clincancerres.aacrjournals.org/content/27/12/3456 @MSKEducation @MSKCC_Library @akrish0294 @rosslevinemd @RichardKoche @ShoronMowla @RossLevineLab #mpnsm
