• Alex Kentsis

  • Nov 02, 2015

Next-Gen Methods in Pharmacology

Welcome to the course page for Next-Gen Methods in Pharmacology!

Graduate Program in Pharmacology, Weill Cornell Medical College and Sloan Kettering Institute

Course Directors: Michael Kharas & Alex Kentsis

This seminar-based course focuses on emerging and state-of-the-art methods in pharmacology using critical review of recently published papers. The goal is to understand current and needed methods for the investigation of drugs and their mechanisms of action, and to develop critical reading skills to evaluate and improve current methodological approaches.

  • Michael Kharas, Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains, Kharas_nbt.3235
  • Daniel Heller, Expansion microscopy, Heller_Science-2015-Chen-543-8, Heller_Chen-SM
  • Olivier Elemento, Using transcriptome sequencing to identify mechanisms of drug action and resistance, Elemento_nchembio.779, Elemento_nchembio.1551
  • Miklos Toth, Pharmacological tools in neuronal circuit mapping, Toth_PNAS-2015-Rei-7291-6
  • Olga Boudker, Single molecule fluorescence methods to detect drug binding and conformational response, Boudker_nature14679
  • Alex Kentsis, Tracking drugs in living cells by thermal profiling of the proteome, Kentsis_Science-2014-Savitski-, Kentsis_Savitski-SM
  • Anthony Sauve, TBD
  • Student Presentations: Please submit your paper selections