Genomic plasticity and somatic DNA transposases and nucleases in developmental cancers

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored.

Epigenetic signaling and its therapeutic blockade in leukemias and solid tumors

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in leukemias and solid tumors. In spite of this, the molecular mechanisms of aberrant cell survival and salient features of disease such as therapy resistance remain elusive.

High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood cancers in particular. The use of massively parallel DNA sequencing is beginning to reveal the extent of non-canonical transcription and splicing in eukaryotic cells but remains hindered by limited genome annotation and inability to discriminate coding reading frames, which in […]