Projects

dna-transposition

Genomic plasticity and DNA transposases in childhood tumors

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored.

adaptive-signaling

Epigenetic signaling and rational therapy of acute myeloid leukemia

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell survival and salient features of disease such as therapy resistance remain elusive.

high-accuracy-mass-spectrometry

High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the extent of non-canonical transcription and splicing in eukaryotic cells but remains hindered by limited genome annotation and inability to discriminate coding reading frames, which in […]