Targeting oncogenic transcription factors
Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
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Human PGBD5 induces DNA transposition
Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
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Alex Kentsis
Blocking disulfide-bridged oncogenic receptor signalling in leukemia using N-acetylcysteine
A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
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Alex Kentsis
Twitter Feed
Load More...Roses are red
Violets are blue
You are 8% virus
And 11% Alu
#AcademicValentineVery excited to share this paper identifying colibactin-derived DNA adducts in human cells and animals! Terrific work from Matt, Yindi, Paul, and our wonderful collaborators in the Balbo, Garrett, Engelward, and Samson labs!!! https://t.co/W1daVFEDRr
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia
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https://t.co/Oj3lrdulqh
By @KentsisResearch and Soheil Meshinchi @fredhutch (together with my @nygenome team)Dreaming of a day when I can do this: Knuth versus Email https://t.co/ergz3oxz1B
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