Targeting oncogenic transcription factors
Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
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Human PGBD5 induces DNA transposition
Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
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Alex Kentsis
Blocking disulfide-bridged oncogenic receptor signalling in leukemia using N-acetylcysteine
A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
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Alex Kentsis
Twitter Feed
Load More...My lab’s new paper describing mutations and copy-number alterations associated with cancer prognosis has been published. We also introduce a web resource – https://t.co/20fFzSgSEu – that will be useful for the cancer research community. https://t.co/nqmm2rGkd2
Whoa! Structure of a cytochrome-based bacterial nanowire. https://t.co/eOPgw37mzf
Our chromatin integration labeling (ChIL) paper was finally published. The idea came up with Yasu Ohkawa 7 years ago, and the first positive data 4 years ago.
https://t.co/82EvWx96lZTADs: cause or consequence of genome function? More discussion 👇👇👇 https://t.co/1i7d4S6pHT
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