Targeting oncogenic transcription factors
Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
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Human PGBD5 induces DNA transposition
Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
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Alex Kentsis
Blocking disulfide-bridged oncogenic receptor signalling in leukemia using N-acetylcysteine
A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
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Alex Kentsis
Twitter Feed
Load More...Small world: who do I see while visiting @Stanford but my @sloan_kettering colleague @whitefishlab who is doing the same.
Wonderful to see this story of the first ever @US_FDA approved therapy for patients with BPDCN in press @NEJM. A true multicenter collaborative effort with special thanks to @doctorpemm, everyone at @Stemline, and of course, our patients. https://t.co/3WuunXa2Qc https://t.co/8rSFtrBTYc
#covalent #PROTACs work! Happy to share the results of this collaborative work on HaloPROTACs @HTovell @chiaramaniaci @mrcppu and @alessiociulli https://t.co/nyXYym982M
The electron beams (cryo EM and micro ED) are here to stay. Things are advancing rapidly - a report from a symposium yesterday:
https://t.co/JewrOOgAMfNice to see this finally published: Engineered peptide barcodes for in-depth analyses of binding protein libraries https://t.co/qeu9bvsaWE
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