Discovery of biomarkers for improved precision in oncology remains a critical problem. This is particularly pressing for cancers that currently lack adequate markers for stratification of chemotherapy and targets for…
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Cross-linking mass spectrometry is a powerful tool to elucidate protein-protein interactions and macromolecular structure based on cross-linker distances between specific amino acid residues. In a recent study led by Zheng…
Read MoreDysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
Read MoreTransposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
Read MoreA subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
Read MoreOutstanding talk by Dr. Alex Kentsis @KentsisResearch describing his work using novel genomic and proteomic approaches for cancer therapy, including #leukemia #leusm @sloan_kettering @WeillCornell
2Improved protein structure prediction using potentials from deep learning https://t.co/o7KdQywMn1
@JaroszLab : A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program https://t.co/JwLBU3TaDA
Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation https://t.co/A8lyzHSshY
