Category archives for Paper

Jan 09, 2018

Targeting oncogenic transcription factors

Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…

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Sep 27, 2015

Human PGBD5 induces DNA transposition

Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…

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Oct 02, 2014

Blocking disulfide-bridged oncogenic receptor signalling in leukemia using N-acetylcysteine

A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…

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