Targeting oncogenic transcription factors
Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
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Human PGBD5 induces DNA transposition
Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
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Alex Kentsis
Blocking disulfide-bridged oncogenic receptor signalling in leukemia using N-acetylcysteine
A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
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Alex Kentsis
Twitter Feed
Load More...From @shorterlab and my remarkable colleague, Lin Guo! Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains https://t.co/sBhHhaeFDe
Nice post about all the latest innovations in flow cytometry! @ISEHSociety https://t.co/LIrohzwsqh
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) out now! Expression of ABCB1 drug transporter can hinder degradation.
@MilkaKostic @JMedChem https://t.co/2euAeRGvaQShame on @JanssenUS
Science hinted that cancer patients could take less of a $148,000-a-year drug. Its maker tripled the price of a pill. https://t.co/SBE7WkvJZ1
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