Discovery of biomarkers for improved precision in oncology remains a critical problem. This is particularly pressing for cancers that currently lack adequate markers for stratification of chemotherapy and targets for…
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Cross-linking mass spectrometry is a powerful tool to elucidate protein-protein interactions and macromolecular structure based on cross-linker distances between specific amino acid residues. In a recent study led by Zheng…
Read MoreDysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
Read MoreTransposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
Read MoreA subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
Read MoreCourts are clogged with millions of debt collection cases. Nearly half are for unpaid medical costs. And although America is not supposed to have debtors prisons, in places like Coffeyville KS, people are getting sent to jail. @propublica https://t.co/iBIvio7zCv
Contribution of retrotransposition to developmental disorders https://t.co/mfdgKjizou #transposon
Read new work from Frederic Kaye and colleagues on new models and therapies for #adenoidcysticcarcinoma including our MYBMIM inhibitor: MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma: https://t.co/gJYPHHbcfW @amyhellerdesign @accrf_org
Latest review from E.Koonin and co.🔥Many interesting thinks about arms race of mobile genetic elements and host defense system. No borders. Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire @NatureRevGenet https://t.co/jG31bhxFqi
