Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
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A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
Read MoreQuestion for #MobDNA17: Could domesticated DNA transposases promote somatic genetic diversification in animal development? RAG1, PGBD5, etc?
A novel plasma DNA testing strategy in Ewing #sarcoma, enabled by #mskimpact @sloankettering:… https://t.co/SDxIHtaHWV
Yet another example of this, wonder if RAG/AID induced? Somatic mutations in patients with rheumatoid arthritis https://t.co/MY6XaGA697
Exciting news, reminds me of the original excitement surrounding this work with Kathy Borden:… https://t.co/GrDtpKGNJR
.@leancerchietti & @drsarahruth found that a drug used to treat hepatitis C may inhibit #lymphoma cell growth.… https://t.co/NvnOs72i0a
New preprint from our lab... The polyploid state plays a tumor suppressive role in the liver https://t.co/3XhcDFG2e9
