Discovery of biomarkers for improved precision in oncology remains a critical problem. This is particularly pressing for cancers that currently lack adequate markers for stratification of chemotherapy and targets for…
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Cross-linking mass spectrometry is a powerful tool to elucidate protein-protein interactions and macromolecular structure based on cross-linker distances between specific amino acid residues. In a recent study led by Zheng…
Read MoreDysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
Read MoreTransposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
Read MoreA subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
Read MoreStructural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 https://t.co/mG7hD1zPHF #bioRxiv
There is still no convincing evidence for the frequent occurrence of posttranslationally spliced HLA-I peptides: https://t.co/DXIDj3qnmC
Psyched to share our work defining the structural basis of DCAF15-dependent RBM39 molecular glue degraders, now posted for feedback on BioRXIV. Congrats Dirk, Jonathan, Josh & colleagues. Gorgeous work, NIBR TPD rules
