Targeting oncogenic transcription factors
Dysregulated control of gene expression is probably one of the essential features of almost every cancer. The causes of this phenomenon vary, but emerging research is converging on the idea…
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Human PGBD5 induces DNA transposition
Transposons are mobile genetic elements that are found in most living organisms. We have now found that human PGBD5 can induce DNA transposition in human cells. The apparent conservation of…
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Alex Kentsis
Blocking disulfide-bridged oncogenic receptor signalling in leukemia using N-acetylcysteine
A subset of human acute lymphoblastic leukemias are driven by mutations of the interleukin-7 receptor (IL7R) and cytokine receptor-like factor 2 (CRLF2), causing aberrant signaling due to disulfide-mediated receptor activation.…
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Alex Kentsis
Twitter Feed
Load More...Up Close and Personal! Congrats to Yosi who got a nice pic in here and will be starting up his own lab soon at @TechnionLive! Thanks to @sloan_kettering and @sciam! https://t.co/GJWjkTvmYy
It is a proud day to see the results of this clinical trial published in @TheLancetOncol https://t.co/2BaTL0gS7M
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib. https://t.co/9fGD1ZTBSb #PrecisionMedicine
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