While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…
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A few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
Read MoreGenetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreThis protocol describes a modified version of flanking sequence exponential anchored (FLEA) PCR. The original FLEA-PCR method was developed to amplify integration sites of retroviruses or retro-transposons. Such transposons contain…
Read MoreStructural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 https://t.co/mG7hD1zPHF #bioRxiv
There is still no convincing evidence for the frequent occurrence of posttranslationally spliced HLA-I peptides: https://t.co/DXIDj3qnmC
Psyched to share our work defining the structural basis of DCAF15-dependent RBM39 molecular glue degraders, now posted for feedback on BioRXIV. Congrats Dirk, Jonathan, Josh & colleagues. Gorgeous work, NIBR TPD rules
