While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…
Read More
A few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
Read MoreGenetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreThis protocol describes a modified version of flanking sequence exponential anchored (FLEA) PCR. The original FLEA-PCR method was developed to amplify integration sites of retroviruses or retro-transposons. Such transposons contain…
Read MoreRoses are red
Violets are blue
You are 8% virus
And 11% Alu
#AcademicValentine
Very excited to share this paper identifying colibactin-derived DNA adducts in human cells and animals! Terrific work from Matt, Yindi, Paul, and our wonderful collaborators in the Balbo, Garrett, Engelward, and Samson labs!!! https://t.co/W1daVFEDRr
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia
https://t.co/Oj3lrdulqh
By @KentsisResearch and Soheil Meshinchi @fredhutch (together with my @nygenome team)
Dreaming of a day when I can do this: Knuth versus Email https://t.co/ergz3oxz1B
