Sample preparation remains essential for high-quality mass spectrometry proteomics. Here, we compared three commonly used methods for protein extraction of frozen mammalian tissues: 1) extraction using SDS buffer followed by…
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While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…
Read MoreA few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
Read MoreGenetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreSo excited to share our publication today! Working with the awesome @markwbudde, A. Granados, and other brilliant minds in the @ElowitzLab, Lois Lab, and @LongCai_Lab, we developed a synthetic recording system to image single cell lineage history. https://science.sciencemag.org/content/372/6538/eabb3099
Excited to share our latest work published today: Silencing of LINE-1 Retrotransposons is a Selective Dependency of Myeloid Leukemia
https://www.nature.com/articles/s41588-021-00829-8
@CRI_UTSW @UTSWNews @NatureGenet
Delighted that our new paper on the role of extrachromosomal DNA elements as mobile enhancers is online. Wonderful collaboration with the lab of Chia-Lin Wei. https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00164-1
Dr. Scott Keeney (@Spo11Rulz) has been studying a protein called Spo11 for two decades. But it wasn't until a postdoc in Dr. Keeney's lab, @ccb_Lab, came along that they were able to answer key questions about Spo11's role in #meiosis. https://bit.ly/3t3VNNY
Sharing this piece about my friend and colleague Buzz Baldwin who passed away last month. https://med.stanford.edu/news/all-news/2021/03/Robert-Baldwin-biochemistry-department-dies-at-93.html Buzz was a pioneer in biochemistry and a wonderful, caring person. We are all missing him @StanfordBiochem.
