While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…
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A few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
Read MoreGenetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreThis protocol describes a modified version of flanking sequence exponential anchored (FLEA) PCR. The original FLEA-PCR method was developed to amplify integration sites of retroviruses or retro-transposons. Such transposons contain…
Read MoreSmall world: who do I see while visiting @Stanford but my @sloan_kettering colleague @whitefishlab who is doing the same.
Wonderful to see this story of the first ever @US_FDA approved therapy for patients with BPDCN in press @NEJM. A true multicenter collaborative effort with special thanks to @doctorpemm, everyone at @Stemline, and of course, our patients. https://t.co/3WuunXa2Qc https://t.co/8rSFtrBTYc
#covalent #PROTACs work! Happy to share the results of this collaborative work on HaloPROTACs @HTovell @chiaramaniaci @mrcppu and @alessiociulli https://t.co/nyXYym982M
The electron beams (cryo EM and micro ED) are here to stay. Things are advancing rapidly - a report from a symposium yesterday:
https://t.co/JewrOOgAMf
Nice to see this finally published: Engineered peptide barcodes for in-depth analyses of binding protein libraries https://t.co/qeu9bvsaWE
