Recent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
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This protocol describes a modified version of flanking sequence exponential anchored (FLEA) PCR. The original FLEA-PCR method was developed to amplify integration sites of retroviruses or retro-transposons. Such transposons contain…
Read MoreMiniaturization of columns for liquid chromatography has greatly enhanced its sensitivity and resolution. Here, we provide a detailed protocol that describes the fabrication of fused silica capillaries with frits and their packing with…
Read MoreIonization efficiency and consequently the sensitivity of mass spectrometric analyses strongly depend on the geometry of nanoelectrospray emitter used, particularly on the terminal inner diameter (ID) of the tip. Here,…
Read MoreFrom @shorterlab and my remarkable colleague, Lin Guo! Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains https://t.co/sBhHhaeFDe
Nice post about all the latest innovations in flow cytometry! @ISEHSociety https://t.co/LIrohzwsqh
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) out now! Expression of ABCB1 drug transporter can hinder degradation.
@MilkaKostic @JMedChem https://t.co/2euAeRGvaQ
Shame on @JanssenUS
Science hinted that cancer patients could take less of a $148,000-a-year drug. Its maker tripled the price of a pill. https://t.co/SBE7WkvJZ1
