Sample preparation remains essential for high-quality mass spectrometry proteomics. Here, we compared three commonly used methods for protein extraction of frozen mammalian tissues: 1) extraction using SDS buffer followed by…
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While computational genomics methods have been greatly advanced by open development in distributed computing environments, computational tools for mass spectrometry proteomics remain tethered to proprietary and often outdated operating systems.…
Read MoreA few years ago, we published a paper reporting PGBD5 as an oncogenic mutator in human cancer. This included measuring its expression in human tissues and mapping its association with…
Read MoreGenetically engineered mouse models of human cancers have proven to be essential for the elucidation of basic molecular mechanisms of cancer pathogenesis and their therapeutic targeting. However, for many genetic…
Read MoreRecent developments in quantitative high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of biochemical analyses of cellular reactions, protein-protein interactions, and small molecule drug discovery.…
Read MoreThink PDL1 activity is a function of tumor burden? Maybe not in some unique INI1 negative pediatric tumors. New study out by Suzanne Forrest and @janeway_MD from @DFBC_PedCare in @CCR_AACR. Can't wait to see what the trial shows. Stay tuned! https://t.co/O4YSdIvcmg
You’ve met histone serotonylation now meet dopaminylation and it’s role in drug related plasticity! @ScienceMagazine #epigenetics Thanks to all our amazing collaborators for their expertise in bringing this together 💪🏻 https://t.co/YuWKie4ERh
AIM2 is highly expressed in neurons, new paper examines its function in brain development, very provocative! https://t.co/SLHuweIvG8
