Functional proteomics
and molecular pharmacology of childhood and developmental cancers

Genomic plasticity and somatic DNA transposases and nucleases in developmental cancers

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. (more…)

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Epigenetic signaling and its therapeutic blockade in leukemias and solid tumors

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in leukemias and solid tumors. In spite of this, the molecular mechanisms of aberrant cell survival and salient…

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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood cancers in particular. The use of massively parallel DNA sequencing is beginning to reveal the…

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Kentsis Research Group Overview

We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and the Tow Center for Developmental Oncology at the Memorial Sloan Kettering Cancer Center. We study the biology of cancers that affect children and young adults ranging from embryonal tumors in infants, leukemias and brain tumors in children, and sarcomas in young adults. Scientists in our group use inter-disciplinary experimental tools as they work to understand the fundamental causes of cancer and to develop definitive therapies for their control.

Projects

Genomic plasticity and somatic DNA transposases and nucleases in developmental cancers
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Epigenetic signaling and its therapeutic blockade in leukemias and solid tumors
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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes
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Publications

Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance
PGBD5 mutator
Childhood cancer mutagenesis caused by a domesticated DNA transposase

Blog

Welcome Anna!
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Meet Isabel Janjigian, 2022 MSK HOPP High School Summer Program Student
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Meet Nathan Rice, 2022 Tri-I Gateways to the Laboratory Summer Program Student
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