Functional proteomics
and molecular pharmacology of childhood and developmental cancers

Genomic plasticity and DNA transposases in childhood tumors

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. (more…)

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Epigenetic signaling and rational therapy of acute myeloid leukemia

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell…

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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the…

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Kentsis Research Group Overview

We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics and the Tow Center for Developmental Oncology at the Memorial Sloan Kettering Cancer Center. We study the biology of cancers that affect children and young adults ranging from embryonal tumors in infants, leukemias and brain tumors in children, and sarcomas in young adults. Scientists in our group use inter-disciplinary experimental tools as they work to understand the fundamental causes of cancer and to develop definitive therapies for their control.

Projects

Genomic plasticity and DNA transposases in childhood tumors
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Epigenetic signaling and rational therapy of acute myeloid leukemia
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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes
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Publications

SAMPEI
Discovery of protein modifications using differential tandem mass spectrometry proteomics
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Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
why2
Why do young people get cancer?

Blog

Webinar on COVID-19 vaccines, genome stability and human gene therapy: The past and future of gene transfer technologies for medicine
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A new year for new science and a new science publishing model: Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
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KRG Outreach: Biology and Pharmacology of Childhood and Developmental Cancers
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