Functional proteomics
and molecular pharmacology of childhood and developmental cancers

Genomic plasticity and DNA transposases in childhood tumors

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. (more…)

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Epigenetic signaling and rational therapy of acute myeloid leukemia

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell…

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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the…

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Kentsis Research Group Overview

We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics at the Memorial Sloan Kettering Cancer Center. We carry out research in cancer biology and pediatric oncology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

Projects

Genomic plasticity and DNA transposases in childhood tumors
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Epigenetic signaling and rational therapy of acute myeloid leukemia
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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes
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Publications

why2
Why do young people get cancer?
devmutator
Developmental mutators and early onset cancer
prohibitin
Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor

Blog

Why do young people get cancer? Developmental mutators, mutagens, and inheritance.
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Post-Doctoral Research Fellow in Functional Cancer Proteomics
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Jumping Genes and Proteomics for New Cancer Therapies: 2019 Distinguished Lecture Series at Sylvester Comprehensive Cancer Center at University of Miami
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