Functional proteomics
and molecular pharmacology of childhood and developmental cancers

Genomic plasticity and DNA transposases in childhood tumors

Half of the human genome originates from mobile DNA elements, or transposons, but their contributions to human disease and physiology remain largely unexplored. (more…)

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Epigenetic signaling and rational therapy of acute myeloid leukemia

Extensive genome sequencing has produced a nearly complete compendium of genetic aberrations in both pediatric and adult acute myeloid leukemias. In spite of this, the molecular mechanisms of aberrant cell…

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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes

Epigenetic dysregulation is becoming increasingly recognized as an important driver of human cancer, and childhood tumors in particular. The use of massively parallel RNA sequencing is beginning to reveal the…

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Kentsis Research Group Overview

We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics at the Memorial Sloan Kettering Cancer Center. We study the biology of cancers that affect children and young adults ranging from embryonal tumors in infants, leukemias and brain tumors in children, and sarcomas in young adults. Scientists in our group use inter-disciplinary experimental tools as they work to understand the fundamental causes of cancer and to develop definitive therapies for their control.

Projects

Genomic plasticity and DNA transposases in childhood tumors
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Epigenetic signaling and rational therapy of acute myeloid leukemia
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High-accuracy mass spectrometry for the discovery and drugging of cancer proteomes
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Publications

why2
Why do young people get cancer?
devmutator
Developmental mutators and early onset cancer
prohibitin
Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor

Blog

KRG Outreach: Biology and Pharmacology of Childhood and Developmental Cancers
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Why Do Young People Get Cancer? PGBD5 and Other Developmental Mutators: 2020 ALSF Virtual Childhood Cancer Lecture
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Three extraction methods for mass spectrometry proteomics of frozen mammalian tissues
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